Endocrinology Quiz #14: Syndrome of Inappropriate Antidiuretic Hormone

1. A 65-year-old man presents to the emergency department with confusion and seizures. His medical history is significant for small cell lung cancer. Laboratory findings reveal serum sodium of 120 mEq/L, urine osmolality of 600 mOsm/kg, and serum osmolality of 260 mOsm/kg. Which of the following is the most likely diagnosis? 

Question 1 of 5

2. A 72-year-old woman with a history of depression is admitted to the hospital for management of hyponatremia. Her medications include sertraline. Laboratory tests reveal serum sodium of 115 mEq/L, serum osmolality of 255 mOsm/kg, and urine osmolality of 500 mOsm/kg. Which of the following is the most appropriate next step in the management of this patient's condition? 

Question 2 of 5

3. A patient with SIADH is being treated with fluid restriction. Which of the following laboratory findings would best indicate a response to this treatment?

Question 3 of 5

4. A 55-year-old man with a recent diagnosis of pneumonia develops headache, nausea, and muscle cramps. Laboratory tests reveal a serum sodium concentration of 128 mEq/L. Urine osmolality is 450 mOsm/kg, and serum osmolality is 260 mOsm/kg. Which of the following underlying conditions is most likely contributing to this patient's symptoms? 

Question 4 of 5

5. A 40-year-old woman is diagnosed with SIADH after presenting with lethargy and confusion. Her serum sodium is 118 mEq/L. Despite appropriate fluid restriction, her sodium levels fail to normalize. Which of the following medications is most appropriate to add to her treatment regimen? 

Question 5 of 5


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