Endocrinology Quiz #19: Thyroid Cancer

1. A 33-year-old woman presents with a palpable nodule in her thyroid gland. Fine-needle aspiration biopsy is performed, and the pathology report indicates the presence of orphan Annie eye nuclei, psammoma bodies, and nuclear grooves. Which of the following is the most likely diagnosis? 

Question 1 of 5

2. A 45-year-old man with a history of exposure to radiation during childhood presents with a thyroid mass. Surgical resection is performed, and histopathology shows a tumor composed of cells with clear cytoplasm arranged in a trabecular pattern. Which of the following mutations is most commonly associated with this type of thyroid cancer? 

Question 2 of 5

3. A 55-year-old woman presents with a rapidly enlarging neck mass, hoarseness, and difficulty swallowing. Biopsy of the mass reveals undifferentiated tumor cells. Which of the following is the most likely diagnosis?

Question 3 of 5

4. A 29-year-old woman with a family history of multiple endocrine neoplasia type 2 (MEN2) is found to have a thyroid nodule. Genetic testing reveals a mutation in the RET proto-oncogene. Which of the following thyroid cancers is she most at risk for developing?

Question 4 of 5

5. A 50-year-old woman is diagnosed with thyroid cancer. Histopathology shows the tumor is composed of follicular cells with extensive vascular and capsular invasion. Which of the following is the most likely diagnosis? 

Question 5 of 5


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