Endocrinology Quiz #22: Cushing Syndrome

1. A 45-year-old woman presents with recent weight gain, particularly around her abdomen, a moon-shaped face, and a buffalo hump. She also complains of easy bruising and thinning of her skin. Laboratory tests reveal elevated levels of cortisol that do not suppress with low-dose dexamethasone but do suppress with high-dose dexamethasone. Which of the following is the most likely diagnosis? 

Question 1 of 5

2. A 30-year-old man presents with hypertension, muscle weakness, and hyperglycemia. On physical exam, he has central obesity, purple striae on his abdomen, and a moon face. An overnight dexamethasone suppression test shows no decrease in cortisol levels. Which of the following tests is most appropriate to differentiate between the causes of Cushing syndrome in this patient? 

Question 2 of 5

3. A 54-year-old woman with a known pituitary adenoma treated with transsphenoidal surgery 1 year ago now presents with recurrent symptoms of Cushing syndrome. Which of the following is the most appropriate next step in management? 

Question 3 of 5

4. A 38-year-old man with ectopic ACTH syndrome due to a small cell lung carcinoma presents with severe Cushing syndrome. Despite treatment of his lung cancer, his hypercortisolemia persists. Which of the following medications is most appropriate to manage his hypercortisolemia? 

Question 4 of 5

5. A 25-year-old woman with Cushing syndrome undergoes a high-dose dexamethasone suppression test. Her cortisol levels decrease significantly following the test. Which of the following is the most likely cause of her condition? 

Question 5 of 5


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