Hem/Onc Quiz #24: Plasma Cell Dyscrasias

1. A 65-year-old man presents with bone pain, particularly in his back and ribs. Laboratory tests reveal hypercalcemia and anemia. Urine protein electrophoresis shows a monoclonal protein band. Which of the following is the most likely diagnosis?

Question 1 of 5

2. A 55-year-old woman presents with fatigue, weight loss, and hepatosplenomegaly. Serum protein electrophoresis reveals a monoclonal IgM spike. Which of the following is the most likely diagnosis?

Question 2 of 5

3. A 70-year-old man is evaluated for numbness in his hands and feet. Biopsy of an affected nerve reveals deposits that stain with Congo red and show apple-green birefringence under polarized light. Which of the following conditions is most likely responsible for his symptoms?

Question 3 of 5

4. A 60-year-old man presents with anemia and a serum protein electrophoresis shows a small monoclonal protein spike. Bone marrow biopsy reveals less than 10% clonal plasma cells. The patient is asymptomatic. Which of the following is the most likely diagnosis?

Question 4 of 5

5. A 58-year-old woman with a history of multiple myeloma treated with chemotherapy presents with severe renal failure. Laboratory tests show elevated BUN and creatinine levels. A kidney biopsy reveals deposits that are lambda light chain restricted. Which of the following is the most likely cause of her renal failure?

Question 5 of 5


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