Hem/Onc Quiz #26: Myeloproliferative Neoplasms

1. A 55-year-old man presents with itching after showers, night sweats, and unexplained weight loss. On physical examination, he is noted to have a ruddy complexion. Laboratory tests reveal elevated hematocrit and leukocyte alkaline phosphatase. Which of the following is the most likely diagnosis?

Question 1 of 5

2. A 60-year-old woman presents with a two-month history of fatigue and headache. Physical examination reveals splenomegaly. Laboratory tests show a platelet count of 800,000/μL. Which of the following is the most likely diagnosis?

Question 2 of 5

3. A 45-year-old male presents with fatigue, night sweats, and fullness in his left upper quadrant. Physical examination reveals marked splenomegaly. A peripheral blood smear shows leukocytosis with a left shift, including myelocytes and basophils. Which of the following genetic abnormalities is most likely associated with his condition?

Question 3 of 5

4. A 70-year-old man presents with bone pain and fatigue. Physical examination is notable for massive splenomegaly. Laboratory tests reveal anemia, leukoerythroblastosis, and teardrop-shaped red cells on peripheral blood smear. Which of the following conditions is he most likely suffering from?

Question 4 of 5

5. A 58-year-old man with a history of increasing tiredness and episodes of sweating during the night undergoes a routine check-up. Physical examination is notable for slight enlargement of the spleen. Laboratory investigations reveal a significantly elevated white blood cell count, predominantly consisting of mature myeloid cells, and a low-grade anemia. Which of the following genetic abnormalities is most commonly associated with this patient’s condition?

Question 5 of 5


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