Hem/Onc Quiz #27: Chromosomal Translocations in Hematologic Neoplasia

1. A 30-year-old woman presents with fatigue, weight loss, and night sweats. Physical examination reveals cervical lymphadenopathy. A biopsy of the lymph node shows Reed-Sternberg cells. Which of the following chromosomal translocations is most commonly associated with this patient's condition? 

Question 1 of 5

2. A 55-year-old man presents with splenomegaly and a white blood cell count of 220,000/μL. A bone marrow biopsy shows increased granulocytes that are positive for the Philadelphia chromosome. Which of the following chromosomal translocations is associated with this finding? 

Question 2 of 5

3. A 50-year-old woman presents with anemia and easy bruising. A bone marrow biopsy reveals promyelocytes with abundant granular cytoplasm and Auer rods. Cytogenetic analysis shows a translocation between chromosomes 15 and 17. Which of the following is the most appropriate initial treatment for this patient?

Question 3 of 5

4. A 62-year-old man presents with generalized lymphadenopathy and a CBC showing lymphocytosis. Flow cytometry of the blood reveals CD5 and CD23 positive B cells. Which of the following chromosomal translocations is most commonly associated with his condition? 

Question 4 of 5

5. A 28-year-old woman presents with fever, bone pain, and an enlarged spleen. A complete blood count shows anemia, thrombocytopenia, and blasts in the peripheral blood. Cytogenetic analysis of the bone marrow reveals a translocation between chromosomes 8 and 21. Which of the following is the most likely diagnosis? 

Question 5 of 5


 

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