Hem/Onc Quiz #6: Hemoglobin Electrophoresis

1. A 6-month-old male infant presents with severe anemia and failure to thrive. Hemoglobin electrophoresis reveals an absence of hemoglobin A (HbA) and a predominance of hemoglobin F (HbF) and small amounts of hemoglobin A2 (HbA2). Which of the following is the most likely diagnosis? 

Question 1 of 5

2. A 15-year-old African American boy is evaluated for mild anemia noted on a routine physical examination. He is asymptomatic and leads an active lifestyle. Hemoglobin electrophoresis demonstrates the presence of hemoglobin S (HbS) and hemoglobin A (HbA). Which of the following is the most likely diagnosis? 

Question 2 of 5

3. During a health screening at a local community center, a 25-year-old woman of Southeast Asian descent has hemoglobin electrophoresis performed as part of a genetic counseling session. The electrophoresis shows a small amount of hemoglobin A (HbA), a large amount of hemoglobin E (HbE), and no hemoglobin H (HbH) or hemoglobin Barts (γ4). What is the most likely genotype of this patient? 

Question 3 of 5

4. A newborn screening test reveals the presence of hemoglobin Barts (γ4) on hemoglobin electrophoresis. Which of the following genetic conditions is most consistent with this finding? 

Question 4 of 5

5. A patient with chronic hemolytic anemia undergoes hemoglobin electrophoresis, which shows an increase in hemoglobin C (HbC) and a decrease in hemoglobin A (HbA). No hemoglobin S (HbS) is detected. Which of the following is the most likely diagnosis? 

Question 5 of 5


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