Hem/Onc Quiz #8: Platelet Plug Formation and Thrombogenesis

1. A 23-year-old man presents to the emergency department after a skateboarding accident with a deep laceration on his forearm. Initial hemostasis is achieved through the rapid adhesion and aggregation of platelets. Which of the following molecules is most critical for the initial adhesion of platelets to the exposed subendothelial collagen?

Question 1 of 5

2. A research laboratory is studying the effects of a new drug that selectively inhibits the COX-1 enzyme in platelets. Which of the following effects is most likely observed in individuals treated with this drug?

Question 2 of 5

3. A 45-year-old woman with a history of recurrent deep vein thrombosis is being evaluated for a possible hypercoagulable state. She is found to have an abnormality in the process of converting fibrinogen to fibrin. This conversion is most directly facilitated by which of the following?

Question 3 of 5

4. During a surgery, a surgeon notes that the patient's blood clotting seems to be less effective than normal. The patient has a history of taking aspirin daily. Aspirin's effect on blood clot formation primarily involves which of the following mechanisms?

Question 4 of 5

5. A 32-year-old man presents to the clinic with easy bruising and frequent nosebleeds. Laboratory tests reveal a prolonged bleeding time with normal prothrombin time (PT) and activated partial thromboplastin time (aPTT). Which phase of hemostasis is most likely impaired in this patient?

Question 5 of 5


 

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