Hem/Onc Quiz #9: Coagulation Cascade and Vitamin K

1. A 3-day-old newborn presents with widespread bruising and a significant bleed after a heel prick test. The newborn's PT is prolonged, but aPTT and TT are normal. Supplementation of which of the following is the most appropriate next step in management? 

Question 1 of 5

2. A 55-year-old man with a history of chronic atrial fibrillation is on long-term anticoagulation therapy. He presents to the emergency department with signs of excessive bleeding following a minor injury. His medication is known to interfere with the synthesis of vitamin K-dependent clotting factors. Which medication is most likely responsible for his condition? 

Question 2 of 5

3. A patient presents with deep vein thrombosis and is started on an anticoagulant that directly inhibits thrombin. Which of the following laboratory tests will be most directly affected by this medication? 

Question 3 of 5

4. A 60-year-old woman with no significant medical history presents to her primary care physician with easy bruising. Laboratory findings show prolonged PT and aPTT, which correct with a mixing study. Further testing reveals a deficiency in a vitamin K-dependent factor. Which of the following factors is LEAST likely to be deficient in this patient? 

Question 4 of 5

5. A researcher is studying the effect of a new drug on the extrinsic pathway of the coagulation cascade. Which of the following laboratory tests should be used to monitor the effect of this drug? 

Question 5 of 5


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