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Question 1 of 23

1. Which of the following cytokines is the primary pyrogen causing fever during an inflammatory response?

Question 1 of 23

Question 2 of 23

2. A 25-year-old male presents with pain and swelling at his great toe joint. Microscopic examination of the synovial fluid shows needle-shaped crystals. Which of the following is the most likely mediator of the acute inflammation seen in this patient's condition?

Question 2 of 23

Question 3 of 23

3. Which of the following eicosanoids is most involved in promoting bronchoconstriction and is implicated in the pathophysiology of asthma?

Question 3 of 23

Question 4 of 23

4. A 32-year-old female patient with a history of systemic lupus erythematosus is experiencing fatigue, joint pain, and a butterfly rash. Which type of hypersensitivity reaction is primarily involved in the pathogenesis of her condition?

Question 4 of 23

Question 5 of 23

5. A patient who received an organ transplant 2 weeks ago is now presenting with fever, jaundice, and diarrhea. A biopsy of the transplanted organ shows dense lymphocytic infiltrates. Which of the following is the most likely diagnosis?

Question 5 of 23

Question 6 of 23

6. A 2-month-old infant receives a routine vaccination that includes a conjugate vaccine. The purpose of conjugating the polysaccharide antigen to a protein is to:

Question 6 of 23

Question 7 of 23

7. A 6-year-old boy with recurrent sinopulmonary infections is found to have low serum levels of IgG and IgA but normal levels of IgM. Which of the following conditions is he most likely suffering from?

Question 7 of 23

Question 8 of 23

8. A 5-month-old male infant presents with recurrent bacterial infections since cessation of breastfeeding. Laboratory findings show undetectable immunoglobulin levels and a lack of B cells. Which genetic defect is most associated with this condition?

Question 8 of 23

Question 9 of 23

9. A 3-year-old boy is brought to the clinic with a history of eczema, recurrent otitis media, and thrombocytopenia with small platelets. Which immunodeficiency condition does this presentation suggest?

Question 9 of 23

Question 10 of 23

10. A 2-year-old child presents with severe bacterial infections and an inability to opsonize bacteria. His serum immunoglobulin levels reveal elevated IgM with very low IgG and IgA. Which condition is most consistent with these findings?

Question 10 of 23

Question 11 of 23

11. A patient with disseminated mycobacterial infection is found to have a defect in the interferon-gamma pathway. Which of the following is most likely deficient in this patient?

Question 11 of 23

Question 12 of 23

12. An infant presents with recurrent viral, bacterial, and fungal infections with a family history of a male sibling dying from infection in early childhood. A diagnosis of SCID is considered. Which of the following laboratory findings is most likely?

Question 12 of 23

Question 13 of 23

13. A 45-year-old woman who has a latex allergy undergoes a surgical procedure and develops urticaria, bronchospasm, and hypotension shortly after the procedure begins. Which type of hypersensitivity reaction is she most likely experiencing?

Question 13 of 23

Question 14 of 23

14. A patient who received a kidney transplant 4 years ago now presents with a gradual increase in serum creatinine and proteinuria. A biopsy of the kidney shows vascular changes with intimal thickening and luminal narrowing. What type of rejection is this patient most likely experiencing?

Question 14 of 23

Question 15 of 23

15. A young adult presents with a history of recurrent Neisseria infections. A deficiency in which of the following components of the immune system is most likely responsible for this susceptibility?

Question 15 of 23

Question 16 of 23

16. A patient with chronic granulomatous disease is at increased risk for infections due to an inability to effectively destroy which type of organisms?

Question 16 of 23

Question 17 of 23

17. A patient is given aspirin for its anti-inflammatory effects. Aspirin's mode of action is primarily through the irreversible inhibition of which of the following enzymes?

Question 17 of 23

Question 18 of 23

18. A patient develops a skin rash, diarrhea, and abnormal liver function tests a few weeks after receiving an allogeneic bone marrow transplant. Which type of cells are primarily responsible for the symptoms of this disease?

Question 18 of 23

Question 19 of 23

19. A 30-year-old woman presents with dry eyes, dry mouth, and recurrent dental carries. Schirmer's test confirms decreased tear production. Which of the following antibodies is most commonly associated with her likely diagnosis?

Question 19 of 23

Question 20 of 23

20. A 24-year-old male presents with increased urinary frequency, thirst, and weight loss despite a normal appetite. Laboratory tests reveal hyperglycemia and low C-peptide levels. Which type of hypersensitivity reaction is primarily involved in the pathogenesis of his condition?

Question 20 of 23

Question 21 of 23

21. A 60-year-old man presents with early satiety, weight loss, and a palpable left upper quadrant mass. His complete blood count shows an elevated white blood cell count with mature and immature granulocytes. A bone marrow biopsy is consistent with a myeloproliferative disorder. Which of the following genetic mutations is most likely associated with his condition?

Question 21 of 23

Question 22 of 23

22. 25-year-old man presents with a painless ulcer on his genitalia and painless lymphadenopathy. Darkfield microscopy of the ulcer shows spirochetes. Which of the following is the most appropriate treatment?

Question 22 of 23

Question 23 of 23

23. A 50-year-old woman presents with bloody diarrhea and abdominal pain. Colonoscopy shows continuous colonic inflammation starting from the rectum. Which of the following additional findings is most suggestive of her likely diagnosis?

Question 23 of 23


 

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