Immunology Quiz#14: Oxidative Burst

1. A 2-year-old boy is brought to the pediatrician due to recurrent infections, including skin abscesses and pneumonia caused by Staphylococcus aureus. Laboratory tests reveal a defect in the oxidative burst in his neutrophils. Which of the following enzymes is most likely deficient in this patient? 

Question 1 of 5

2. A researcher is studying the mechanism of action of neutrophils in combating bacterial infections. She notes that one of the key processes involves the conversion of oxygen to a highly reactive molecule that initiates a cascade resulting in the production of bleach within the phagolysosome. Which molecule is the initial product of this oxidative burst? 

Question 2 of 5

3. During a seminar on the immune response to bacterial pathogens, a speaker highlights the importance of a specific enzymatic reaction in producing a potent antimicrobial agent within neutrophils. This agent is responsible for killing bacteria through protein denaturation. The enzyme involved uses hydrogen peroxide and chloride ion as substrates. Which enzyme is being described? 

Question 3 of 5

4. A newborn girl is diagnosed with a genetic disorder characterized by an increased susceptibility to bacterial and fungal infections. Further investigation reveals a dysfunction in the oxidative killing mechanism of her phagocytes. This disorder is likely to result from a defect in the assembly or function of which of the following components? 

Question 4 of 5

5. A clinical trial is evaluating a new drug designed to enhance the antimicrobial capacity of neutrophils. The drug specifically increases the production of a reactive oxygen species that is a precursor to other antimicrobial agents within the phagolysosome. This ROS is also involved in the conversion of xanthine dehydrogenase to xanthine oxidase during ischemic conditions. Which ROS is being targeted by this drug? 

Question 5 of 5


 

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