Immunology Quiz #6: HLA Subtypes and diseases

1. A 25-year-old male presents with back pain and stiffness that improves with exercise but not with rest. Radiographic examination shows sacroiliitis. Laboratory testing is most likely to reveal which of the following HLA subtypes? 

Question 1 of 5

2. A 32-year-old female with a history of dry eyes and dry mouth is diagnosed with Sjögren's syndrome. Which of the following HLA subtypes is most likely associated with her condition? 

Question 2 of 5

3. A 40-year-old man presents with symmetric polyarthritis affecting his hands. Rheumatoid factor and anti-citrullinated protein antibodies are present in his serum. Which HLA subtype is most commonly associated with this condition? 

Question 3 of 5

4. A previously healthy 28-year-old woman develops neurological symptoms, including numbness and weakness. She undergoes a brain MRI which is shown below. Which HLA subtype is most strongly associated with her likely diagnosis? 

Question 4 of 5

5. A 9-year-old boy is brought to the clinic by his parents due to abdominal pain, diarrhea, and weight loss. A biopsy of the small intestine shows villous atrophy. Which of the following HLA subtypes is most commonly associated with his likely diagnosis? 

Question 5 of 5


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