Immunology Quiz #8: Differentiation of T cells

1. A 22-year-old female presents with a skin rash and joint pain. Laboratory studies show high levels of autoantibodies. Further testing indicates a high level of CD4+ T cells producing IL-4, IL-5, and IL-13. This differentiation of CD4+ T cells is most likely induced by which of the following cytokines? 

Question 1 of 5

2. A 30-year-old male is diagnosed with a chronic infection characterized by intracellular bacteria. His immune response is primarily mediated by CD4+ T cells that produce IFN-γ and IL-2. This pattern of cytokine production is characteristic of differentiation into which type of T helper cell? 

Question 2 of 5

3. During a study of the immune response to fungal infections, it is noted that a certain subset of CD4+ T cells plays a critical role by producing IL-17. This subset of T cells, important for the defense against extracellular bacteria and fungi, differentiates in the presence of which of the following cytokines? 

Question 3 of 5

4. A researcher is studying a regulatory mechanism of the immune system that prevents autoimmune diseases. She is particularly interested in a subset of CD4+ T cells that express the transcription factor Foxp3 and are known for their immunosuppressive functions. The differentiation of these T cells is primarily promoted by which cytokine? 

Question 4 of 5

5. A 45-year-old man with a history of chronic hepatitis B virus infection is undergoing evaluation. His immune response shows an increased presence of a specific subset of CD4+ T cells that facilitate B cell differentiation into plasma cells. This subset of T cells is most likely characterized by the production of which cytokine? 

Question 5 of 5


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