Integumentary system Quiz #12, Autoimmune Blistering Skin Diseases  

1. A 55-year-old man presents with flaccid bullae on his trunk and oral mucosa. Biopsy of the lesion shows acantholysis in the epidermis. Direct immunofluorescence of the skin biopsy reveals IgG antibodies against intercellular spaces in the epidermis. Which of the following is the most likely diagnosis? 

Question 1 of 5

2. A 70-year-old woman presents with tense blisters on her forearms and thighs, sparing the mucous membranes. Biopsy of the lesion and immunofluorescence studies would most likely show which of the following? 

Question 2 of 5

3. A 45-year-old man presents with pruritic vesicles over his elbows and knees. He also complains of gastrointestinal discomfort. Skin biopsy shows neutrophils at the tips of dermal papillae and granular IgA deposits in the dermal papillae on immunofluorescence. Which of the following conditions is most closely associated with this patient's skin findings? 

Question 3 of 5

4. A 60-year-old woman presents with widespread blistering lesions. A skin biopsy is performed, showing subepidermal blisters with eosinophils. Direct immunofluorescence of the skin reveals linear IgG and C3 deposition along the basement membrane. Which of the following best describes the target of the antibodies in this patient's condition? 

Question 4 of 5

5. A 25-year-old woman presents with painful blisters on her hands and feet which worsen with sun exposure. Histological examination of a blister shows subepidermal blistering with little to no inflammation. Immunofluorescence shows IgG deposition at the dermal-epidermal junction. Which of the following is the most likely environmental trigger for this patient's condition? 

Question 5 of 5


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