Integumentary system Quiz #17, Melanoma  

1. A 45-year-old man presents with a pigmented lesion on his back that has changed in color and size over the past 6 months. Physical examination reveals a 1.2 cm asymmetric lesion with irregular borders, varying colors, and a slight elevation. Which of the following genetic mutations is most commonly associated with this type of skin cancer? 

Question 1 of 5

2. During a skin examination, a 55-year-old woman is found to have a melanoma with a Breslow depth of 2.3 mm on her upper arm. Which of the following is the most appropriate next step in management? 

Question 2 of 5

3. A 50-year-old man with a history of multiple sunburns during childhood presents with a mole on his chest that has become increasingly dark. Biopsy of the lesion reveals melanoma. Which of the following is the most significant risk factor for developing this condition in this patient? 

Question 3 of 5

4. A 35-year-old woman presents for evaluation of a mole on her leg that she believes has changed in appearance. On examination, the mole is noted to be asymmetric, with irregular borders and multiple colors. A biopsy is performed and confirms melanoma. Sentinel lymph node biopsy is negative. Which of the following features is the strongest predictor of survival in this patient? 

Question 4 of 5

5. A 30-year-old woman with fair skin and a history of frequent tanning bed use during her teenage years presents with a new pigmented lesion on her abdomen. The lesion is 8 mm in diameter, asymmetric, with an irregular border and heterogeneous coloring. Which of the following features of this lesion is most concerning for melanoma? 

Question 5 of 5


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