MSK Quiz#22, Osteomalacia and Osteopetrosis  

1. A 55-year-old postmenopausal woman presents with a history of generalized bone pain and muscle weakness. Laboratory findings reveal a low serum calcium level, low phosphorus, elevated alkaline phosphatase, and a low level of 25-hydroxyvitamin D. Which of the following is the most likely diagnosis? 

Question 1 of 5

2. A 70-year-old woman with a history of multiple fractures presents for evaluation. She has a kyphotic posture and decreased height. Bone density testing shows a T-score of -2.8. Which of the following factors is most important in the pathogenesis of her condition? 

Question 2 of 5

3. A 63-year-old man complains of diffuse bone pain and weakness. Laboratory tests reveal a normal calcium level, decreased serum phosphorus, elevated alkaline phosphatase, and decreased 25-hydroxyvitamin D. Radiographs show Looser's zones. Which of the following treatments is most appropriate? 

Question 3 of 5

4. A 58-year-old female with rheumatoid arthritis on long-term glucocorticoid therapy presents with a recent distal radius fracture from a fall at home. Bone mineral density testing shows a T-score of -2.5. Which of the following is a major contributing factor to her bone condition? 

Question 4 of 5

5. In a patient with osteomalacia, which of the following histological findings is expected during a bone biopsy? 

Question 5 of 5


 

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