MSK Quiz#25, Rheumatoid Arthritis  

1. A 55-year-old female with a history of smoking presents with morning stiffness that lasts more than one hour and improves with activity. She has symmetrical joint pain involving her wrists and fingers. Laboratory findings reveal elevated ESR, CRP, and positive anti-CCP antibodies. Which of the following is the most likely diagnosis? 

Question 1 of 5

2. A patient with rheumatoid arthritis is being evaluated for medication management. Which of the following drugs is primarily used as a disease-modifying antirheumatic drug (DMARD) and requires regular monitoring of liver enzymes and complete blood count due to its potential myelosuppressive effects? 

Question 2 of 5

3. A 48-year-old male with rheumatoid arthritis presents with a new onset of shortness of breath and a dry cough. On examination, you note digital clubbing. High-resolution CT reveals interstitial lung disease. Which of the following rheumatoid arthritis manifestations is most directly related to these findings? 

Question 3 of 5

4. A 60-year-old woman with rheumatoid arthritis complains of pain in her elbow. On physical examination, you notice a subcutaneous nodule near the olecranon. Histologic examination of this nodule would most likely reveal which of the following? 

Question 4 of 5

5. Which of the following antibodies is most specific for the diagnosis of rheumatoid arthritis? 

Question 5 of 5


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