MSK Quiz#27, Sjogren Syndrome and Juvenile Arthritis  

1. A 45-year-old female presents to the clinic complaining of dry eyes and dry mouth for the past six months. She also mentions joint pain and fatigue. Serological testing shows positive Anti-Ro (SSA) and Anti-La (SSB) antibodies. Schirmer's test confirms decreased tear production. Which of the following is the most likely diagnosis? 

Question 1 of 5

2. A 3-year-old girl is brought to the pediatrician by her parents, who are concerned about her limping in the morning. They also report that she has had a persistent fever for the past two weeks. Laboratory findings include an elevated ESR and ANA positivity. Which of the following is the most appropriate next step in management? 

Question 2 of 5

3. A 12-year-old boy with a history of juvenile idiopathic arthritis presents with high fever, evanescent salmon-pink rash, and generalized lymphadenopathy. Laboratory tests reveal leukocytosis and elevated liver enzymes. Which subtype of juvenile idiopathic arthritis is most likely present in this patient? 

Question 3 of 5

4. A 55-year-old female with a known history of Sjögren's syndrome presents with worsening fatigue and joint pain. She also reports experiencing a dry cough and shortness of breath. High-resolution CT scan of the chest shows interstitial lung disease. Which of the following autoantibodies is most closely associated with pulmonary involvement in this condition? 

Question 4 of 5

5. A 7-year-old female is diagnosed with oligoarticular juvenile idiopathic arthritis affecting her right knee. Despite NSAID therapy, she continues to experience pain and swelling in the affected joint. Which of the following is the most appropriate next step in management? 

Question 5 of 5


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