MSK Quiz#29, Systemic Lupus Erythematosus 

1. A 25-year-old woman presents with fatigue, joint pain, and a facial rash that worsens with sun exposure. Laboratory tests reveal hemolytic anemia, leukopenia, and proteinuria. Anti-nuclear antibody (ANA) test is positive, and anti-double-stranded DNA (anti-dsDNA) antibodies are also detected. Which of the following is the most likely diagnosis? 

Question 1 of 5

2. A 30-year-old female with a known diagnosis of systemic lupus erythematosus (SLE) presents with new-onset seizures. MRI of the brain is unremarkable. Which of the following autoantibodies is most strongly associated with neuropsychiatric manifestations in SLE? 

Question 2 of 5

3. A 28-year-old female with systemic lupus erythematosus (SLE) is being evaluated for potential treatments. She has been experiencing severe malar rash, arthritis, and nephritis. Which of the following medications is contraindicated in this patient due to the risk of exacerbating her condition? 

Question 3 of 5

4. A 32-year-old woman with systemic lupus erythematosus (SLE) presents with fever, malaise, and worsening renal function. A renal biopsy is performed and shows diffuse proliferative glomerulonephritis. Which of the following findings is commonly associated with this renal pathology in the context of SLE? 

Question 4 of 5

5. A 27-year-old female with systemic lupus erythematosus (SLE) complains of dry eyes and dry mouth. Schirmer's test confirms decreased tear production, and a lip biopsy shows lymphocytic infiltration of the salivary glands. Which of the following best describes this condition seen in conjunction with SLE? 

Question 5 of 5


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