MSK Quiz#30, Antiphospholipid Syndrome  

1. A 34-year-old woman with a history of systemic lupus erythematosus (SLE) presents with recurrent first-trimester miscarriages. She has no previous history of thrombosis. Laboratory evaluation reveals prolonged PTT that does not correct with mixing studies, and positive lupus anticoagulant testing. Which of the following is the most appropriate initial treatment for this condition? 

Question 1 of 5

2. A 45-year-old man presents with a sudden onset of right-sided weakness. His past medical history is significant for deep vein thrombosis and one unprovoked pulmonary embolism. Laboratory tests reveal a positive anticardiolipin antibody. Which of the following is the most likely diagnosis? 

Question 2 of 5

3. Which of the following laboratory findings is most specific for the diagnosis of antiphospholipid syndrome (APS)? 

Question 3 of 5

4. A 38-year-old female with antiphospholipid syndrome (APS) on long-term anticoagulation with warfarin is planning to conceive. Which of the following changes to her management is recommended during pregnancy? 

Question 4 of 5

5. A 32-year-old woman with antiphospholipid syndrome (APS) presents with a cold, pale left leg. Angiography shows arterial thrombosis. Despite treatment with unfractionated heparin, her symptoms do not improve. Which of the following is the most appropriate next step in management? 

Question 5 of 5


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