MSK Quiz#34, Neuromuscular Junction Diseases  

1. A 28-year-old woman presents with fluctuating muscle weakness that worsens towards the evening and after prolonged activity. Examination reveals ptosis and diplopia that improve after administration of edrophonium. Which of the following is the most likely diagnosis? 

Question 1 of 5

2. A 60-year-old man with a history of small cell lung cancer presents with muscle weakness, especially in the proximal lower limbs, that improves with muscle use. He also reports dry mouth and erectile dysfunction. Electromyography shows an incremental response to repetitive nerve stimulation. Which of the following antibodies is most likely to be present? 

Question 2 of 5

3. A 3-year-old boy presents with acute onset of generalized muscle weakness following a gastrointestinal infection. His parents report that he has been unable to stand or walk. Examination reveals diminished deep tendon reflexes. Which of the following is the most likely mechanism of his condition? 

Question 3 of 5

4. A patient presents with double vision, difficulty swallowing, and muscle weakness that began several hours after eating canned food. Which of the following is the most likely cause of these symptoms? 

Question 4 of 5

5. A 45-year-old woman presents with progressive weakness and sensory changes. Electromyography shows decreased compound muscle action potentials (CMAPs) with normal sensory nerve action potentials (SNAPs). Repetitive nerve stimulation reveals a decremental response. Which of the following treatments is most appropriate for this patient? 

Question 5 of 5


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