MSK Quiz#35, Scleroderma and Raynaud Phenomenon

1. A 52-year-old woman presents with difficulty swallowing, tightness of the skin on her face and hands, and episodes of fingertip color changes in response to cold temperatures. A skin biopsy from her forearm shows thickened collagen bundles and decreased capillaries in the dermis. Which of the following autoantibodies is most likely to be positive in this patient? 

Question 1 of 5

2. A 30-year-old woman reports episodes of her fingers turning white and blue in cold weather or during stress, followed by redness upon rewarming. Which of the following is the most likely diagnosis? 

Question 2 of 5

3. A 45-year-old man with a history of scleroderma presents with new-onset hypertension and a serum creatinine increase from 1.0 mg/dL to 1.9 mg/dL over the past year. Renal biopsy would most likely show which of the following features? 

Question 3 of 5

4. A patient with systemic sclerosis is at increased risk for developing which of the following pulmonary complications? 

Question 4 of 5

5. A 34-year-old female with scleroderma presents with complaints of heartburn and regurgitation, especially at night. Which of the following is the most appropriate initial management for her symptoms?

Question 5 of 5


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