Pathology Quiz #1: Cellular Adaptations

1. A 45-year-old man with a 30-year history of smoking presents to his primary care physician complaining of a persistent cough. A biopsy of his bronchial epithelium reveals squamous metaplasia. This cellular adaptation is most likely a result of which of the following mechanisms? 

Question 1 of 5

2. A 55-year-old woman undergoes an upper endoscopy for evaluation of chronic gastroesophageal reflux disease (GERD). Biopsy of the lower esophagus shows columnar metaplasia. This finding is indicative of which of the following conditions? 

Question 2 of 5

3. During a routine screening colonoscopy, a 60-year-old man is found to have a 2 cm polyp in his descending colon. Histologic examination of the polyp after removal shows dysplasia characterized by cellular atypia and loss of normal tissue architecture. Dysplasia in this context is best described as: 

Question 3 of 5

4. A pathologist examines a biopsy from the cervix of a 32-year-old woman during a routine Pap smear. The sample shows dysplastic cells with increased nuclear size, hyperchromasia, and irregular nuclear contours. These cellular changes are most directly related to which of the following processes? 

Question 4 of 5

5. A 50-year-old man with a long-standing history of chronic pancreatitis undergoes an endoscopic ultrasound. Fine-needle aspiration of the pancreas reveals the presence of pancreatic intraepithelial neoplasia (PanIN) with dysplastic cells showing nuclear enlargement, prominent nucleoli, and loss of polarity. This lesion is most likely indicative of which of the following in the context of his medical history? 

Question 5 of 5


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