Pathology Quiz #10: Acute Phase Reactants

1. A 45-year-old male presents to the clinic with complaints of morning stiffness that improves with activity, bilateral wrist swelling, and tenderness for the past two months. Laboratory findings show elevated erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels. Which of the following proteins is most directly responsible for the increase in ESR in this patient? 

Question 1 of 5

2. During an episode of acute inflammation, the liver is stimulated to produce a number of acute phase proteins. Which of the following is the primary cytokine responsible for inducing the synthesis of most acute phase reactants? 

Question 2 of 5

3. A 32-year-old woman with a history of systemic lupus erythematosus (SLE) presents to the emergency department with a four-day history of fever and arthralgia. Laboratory tests reveal an elevated C-reactive protein (CRP). Which of the following best describes the function of the protein elevated in this patient's blood? 

Question 3 of 5

4. Which of the following acute phase reactants directly inhibits proteolysis and exhibits antifibrinolytic properties by binding to plasminogen, thus preventing its conversion to plasmin? 

Question 4 of 5

5. A 53-year-old man with a history of chronic obstructive pulmonary disease (COPD) presents with an acute exacerbation characterized by increased dyspnea, wheezing, and productive cough. His treatment regimen is adjusted, and a course of antibiotics is initiated. Which of the following acute phase reactants is most likely to decrease in response to successful treatment of this exacerbation? 

Question 5 of 5


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