Pathology Quiz #12: Chronic Inflammation

1. A 60-year-old male with a 40-year history of smoking presents to his physician complaining of a persistent cough and weight loss. A chest X-ray reveals a mass in the upper lobe of the right lung. Biopsy of the mass shows epithelioid cells and Langhans-type giant cells surrounding a central area of necrosis. Which of the following is the most likely mechanism of the granuloma formation observed in this patient? 

Question 1 of 5

2. A 45-year-old woman with a history of rheumatoid arthritis complains of constant fatigue and joint pain. Laboratory tests reveal elevated levels of autoantibodies and an increase in acute phase reactants. Which of the following cell types plays a key role in sustaining the chronic inflammation observed in this patient? 

Question 2 of 5

3. A 55-year-old male with a history of poorly controlled diabetes mellitus type 2 presents with a non-healing ulcer on his right foot. Histologic examination of the ulcer border reveals an abundance of lymphocytes and plasma cells. Which of the following best describes the underlying process of the non-healing nature of this ulcer? 

Question 3 of 5

4. An 80-year-old woman presents with memory loss and confusion. MRI of the brain reveals multiple areas of white matter hyperintensities. Histopathology of these areas would most likely show which of the following findings? 

Question 4 of 5

5. A 30-year-old man presents with abdominal pain and bloody diarrhea. Colonoscopy reveals continuous colonic ulcers starting from the rectum. Biopsy of the affected mucosa shows crypt abscesses and a high number of plasma cells and lymphocytes. Which of the following cytokines is most implicated in maintaining the chronic inflammatory state in this patient? 

Question 5 of 5


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