Pathology Quiz #14: Granulomatous Inflammation

1. A 34-year-old female presents with a persistent cough, night sweats, and weight loss over the past two months. A chest X-ray reveals a cavitary lesion in the upper lobe of the right lung. Sputum smears are positive for acid-fast bacilli. Which of the following cell types is most responsible for the formation of the granuloma observed in this patient? 

Question 1 of 4

2. A 50-year-old man with a history of sarcoidosis presents with dyspnea and dry cough. A chest CT scan shows bilateral hilar lymphadenopathy and a tissue biopsy is obtained. A histopathology image of the biopsy specimen is shown below. Which of the following cytokines is most implicated in the pathophysiology of the lesion shown in the histology image? 

Question 2 of 4

3. A 28-year-old woman presents with a painful rash on her legs. Physical examination reveals tender, red nodules. An image of the skin lesions is shown below. Biopsy of a lesion shows granulomatous inflammation with neutrophils surrounding necrotic fat tissue. Which of the following is the most likely diagnosis? 

Question 3 of 4

4. A researcher is studying a new infectious agent isolated from patients with granulomatous inflammation of the lymph nodes. When macrophages are exposed to this agent in vitro, they secrete large amounts of IL-12. Which of the following immune responses is most likely enhanced by IL-12 in this context? 

Question 4 of 4


 

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