Pathology Quiz #16: Neoplasia

1. A 55-year-old man presents with a rapidly growing mass on his left kidney. Imaging studies suggest a renal cell carcinoma. Biopsy and genetic analysis of the tumor reveal a loss of function mutation in the VHL gene. This mutation is best characterized as which of the following? 

Question 1 of 4

2. A 40-year-old woman undergoes a biopsy of a suspicious breast lump. Histopathology reveals cells with increased nuclear-to-cytoplasmic ratios and prominent nucleoli. Additionally, there is evidence of neoplastic cells invading surrounding adipose tissue. These findings are indicative of which of the following? 

Question 2 of 4

3. During a routine check-up, a 50-year-old man is found to have a 5 cm mass in his colon on colonoscopy. A biopsy of the mass is performed, and histological examination shows the neoplastic cells forming glandular structures. Immunohistochemistry is positive for cytokeratin. This tumor is most likely derived from which of the following types of tissue? 

Question 3 of 4

4. A study is conducted on a group of patients with chronic hepatitis C infection. It is observed that these patients have an increased risk of developing hepatocellular carcinoma over time. Which of the following best explains the increased risk of cancer in these patients? 

Question 4 of 4


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