Pathology Quiz #2: Cell Injury, Apoptosis, and Necrosis

1. A 55-year-old male with a history of chronic alcohol abuse presents to the emergency department with severe abdominal pain. Laboratory tests reveal elevated amylase and lipase levels. Histopathological examination of the pancreas shows cells with ruptured plasma membranes and enzymatic digestion of cellular contents. Which of the following types of cell death is most likely occurring in the pancreas? 

Question 1 of 5

2. A 60-year-old female with a long history of smoking is diagnosed with lung cancer. A biopsy of the tumor reveals cells undergoing programmed cell death characterized by cell shrinkage, chromatin condensation, and formation of apoptotic bodies. Which of the following best describes this process? 

Question 2 of 5

3. During a pathology lecture, a professor discusses the mechanism of cell injury in ischemic conditions. She explains that reduction in ATP levels leads to failure of which of the following cellular components, contributing significantly to cell injury? 

Question 3 of 5

4. A laboratory study on hepatocytes treated with a toxin reveals cellular death characterized by extensive cytoplasmic vacuolization and mitochondrial swelling, but without initial rupture of the plasma membrane. This form of cell death is most likely mediated by which of the following processes? 

Question 4 of 5

5. A 45-year-old male with a history of hypertension and hyperlipidemia presents to his physician complaining of chest pain. An ECG and cardiac biomarkers confirm a diagnosis of myocardial infarction. Histopathology of the affected myocardium would most likely reveal which type of necrosis? 

Question 5 of 5


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