Pathology Quiz #20: Oncogenes and Tumor Suppressor Genes

1. A 30-year-old woman presents with multiple endocrine neoplasia type 1 (MEN1), exhibiting tumors of the parathyroid glands, pancreatic islets, and anterior pituitary. Genetic testing reveals a mutation in a gene that encodes a protein acting as a tumor suppressor. Which of the following genes is most likely mutated in this patient? 

Question 1 of 4

2. A research team is studying a family with a high incidence of colorectal cancer. They identify a mutation that results in a truncated protein product, leading to increased cell proliferation. This mutation is most likely found in which of the following types of genes? 

Question 2 of 4

3. A 56-year-old male with chronic myelogenous leukemia (CML) has a chromosomal abnormality involving the translocation between chromosomes 9 and 22, resulting in the formation of a fusion gene. This gene is known to encode for a protein with increased tyrosine kinase activity. Which of the following is the fusion gene responsible for this condition? 

Question 3 of 4

4. A 45-year-old woman is diagnosed with breast cancer after a lump was found during a routine mammogram. Genetic testing reveals a mutation in a gene known for its role in DNA repair. Mutations in this gene significantly increase the risk for developing breast and ovarian cancer. Which of the following genes is most likely mutated in this patient? 

Question 4 of 4


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