Pathology Quiz #8: Amyloidosis

1. A 60-year-old man with a history of chronic inflammatory arthritis presents with proteinuria and renal insufficiency. A renal biopsy shows apple-green birefringence under polarized light after Congo red staining. Which of the following is the most likely type of amyloidosis in this patient? 

Question 1 of 5

2. A 65-year-old woman with a history of carpal tunnel syndrome and heart failure with preserved ejection fraction undergoes a fat pad biopsy that reveals amyloid deposits. Which of the following proteins is most likely to be found in the amyloid deposits of this patient? 

Question 2 of 5

3. A 50-year-old man with a history of multiple myeloma presents with kidney failure. Biopsy shows deposition of amyloid fibrils in the glomeruli. Which of the following is the most likely component of the amyloid fibrils in this patient? 

Question 3 of 5

4. During a study session, a group of medical students discusses a case of a patient with restrictive cardiomyopathy and macroglossia. Biopsy of the affected organs shows amyloid deposition. Which of the following tests is most useful for identifying the specific type of amyloid protein involved in this patient's condition? 

Question 4 of 5

5. A 70-year-old man presents with worsening peripheral neuropathy and a history of chronic heart failure. Laboratory tests reveal elevated B-type natriuretic peptide (BNP) and troponin T levels. A diagnosis of amyloidosis is suspected. Which of the following features on echocardiography would most likely support this diagnosis? 

Question 5 of 5


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