Pharmacology Quiz #28: Biologic Agents

1. A 25-year-old woman with moderate to severe rheumatoid arthritis who has failed methotrexate therapy is started on a new medication. This medication is a recombinant DNA-derived monoclonal antibody that inhibits tumor necrosis factor-alpha (TNF-α). Which of the following drugs has this patient most likely been prescribed? 

Question 1 of 5

2. A 32-year-old man with severe plaque psoriasis is started on a new biologic therapy after other treatments have failed. This drug is a human monoclonal antibody that targets the p40 subunit of IL-12 and IL-23, cytokines involved in the pathogenesis of psoriasis. Which of the following medications has been prescribed? 

Question 2 of 5

3. A patient with chronic lymphocytic leukemia (CLL) is treated with a monoclonal antibody that targets CD20, a protein expressed on the surface of B cells. This treatment leads to the destruction of malignant B cells. Which of the following drugs has this patient been administered? 

Question 3 of 5

4. A 40-year-old man with moderate to severe Crohn's disease is started on a monoclonal antibody therapy after failing to respond to conventional treatment. This drug specifically inhibits the α4β7 integrin, reducing lymphocyte migration to the gut. Which of the following medications has the patient been prescribed? 

Question 4 of 5

5. A 50-year-old woman with severe, active, and progressive multiple sclerosis (MS) not responsive to first-line treatments is started on a humanized monoclonal antibody that targets the α4-subunit of integrins expressed on the surface of all leukocytes except neutrophils. This mechanism prevents the crossing of leukocytes across the blood-brain barrier. Which of the following drugs has been prescribed? 

Question 5 of 5


 

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