Pharmacology Quiz #3: Drug Metabolism

1. A 40-year-old male with a history of chronic alcohol abuse is prescribed a medication that is primarily metabolized by the liver's cytochrome P450 system. The patient is at increased risk for which of the following outcomes regarding drug metabolism? 

Question 1 of 5

2. A new medication is found to be a strong inhibitor of CYP3A4. Co-administration of this medication with a drug that is a substrate of CYP3A4 would likely result in which of the following? 

Question 2 of 5

3. A patient is prescribed a drug that is known to undergo extensive first-pass metabolism. Which of the following routes of administration would most effectively bypass first-pass metabolism and increase the bioavailability of the drug? 

Question 3 of 5

4. A medication used for the treatment of hypertension is known to be metabolized by phase II conjugation reactions without undergoing phase I oxidation. Which of the following is most likely involved in the metabolism of this drug? 

Question 4 of 5

5. A research study evaluates the metabolism of a new anti-anxiety medication and finds that its clearance is significantly reduced in elderly patients. Which of the following age-related changes is most likely responsible for this observation? 

Question 5 of 5


 

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