Pharmacology Quiz #4: Elimination of Drugs

1. A 40-year-old man with a history of chronic alcohol abuse is prescribed a medication that is known to be metabolized primarily by the liver. Which of the following alterations in drug elimination is most likely to occur in this patient? 

Question 1 of 5

2. A new oral medication for type 2 diabetes shows a high first-pass effect. Which of the following is a likely characteristic of this medication? 

Question 2 of 5

3. A patient with renal failure is administered a drug that is known to be eliminated unchanged in the urine. Which pharmacokinetic change is primarily expected in this patient? 

Question 3 of 5

4. A medication used to treat hypertension is noted to follow zero-order kinetics at therapeutic doses. Which of the following best describes the elimination of this drug? 

Question 4 of 5

5. In a patient undergoing treatment with a drug that is known to be a substrate for P-glycoprotein (P-gp), which of the following factors could potentially increase the drug's oral bioavailability? 

Question 5 of 5


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