Psychiatry Quiz #13: Major Depressive Disorder

1. A 27-year-old woman presents to her primary care physician with complaints of persistent sadness, loss of interest in activities she used to enjoy, significant weight loss, insomnia, and feelings of worthlessness over the past 3 months. She mentions difficulty concentrating at work and has recurrent thoughts of death. Which of the following is the most likely diagnosis? 

Question 1 of 5

2. A 35-year-old man is diagnosed with major depressive disorder. Despite initial treatment with sertraline, he reports minimal improvement in his depressive symptoms after 6 weeks. What is the most appropriate next step in managing this patient's condition? 

Question 2 of 5

3. A 42-year-old woman with major depressive disorder is being treated with fluoxetine. She returns for a follow-up visit and reports experiencing excessive sweating, insomnia, and diarrhea since starting the medication. These findings are most consistent with which of the following? 

Question 3 of 5

4. A 30-year-old man with a history of major depressive disorder is being evaluated for treatment-resistant depression after failing to respond to two adequate trials of antidepressants from different classes. Which of the following treatment options is most appropriate to consider next? 

Question 4 of 5

5. A 25-year-old female patient presents with complaints of depressed mood, significant weight gain, hypersomnia, and rejection sensitivity for the past year. These symptoms seem to worsen during the winter months and improve during the summer. Which of the following is the most likely diagnosis? 

Question 5 of 5


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