Genetics Quiz #3: Nucleotide Synthesis and Metabolism

1. A 4-month-old infant is brought to the clinic due to failure to thrive and severe combined immunodeficiency. Laboratory tests reveal a significant deficiency in both T and B cell numbers. Which enzyme deficiency is most likely responsible for these findings?

Question 1 of 5

2. A researcher is studying a new drug that inhibits the enzyme dihydroorotate dehydrogenase. This enzyme is critical in the synthesis of which of the following nucleotides?

Question 2 of 5

3. A patient with a history of frequent bacterial infections is found to have elevated levels of dGTP in his lymphocytes. Which of the following enzymes is most likely deficient in this patient?

Question 3 of 5

4. A patient is diagnosed with orotic aciduria after presenting with megaloblastic anemia that did not improve with vitamin B12 or folate supplementation. This disorder is most likely due to a deficiency in which of the following enzymes?

Question 4 of 5

5. A 25-year-old male presents with gouty arthritis. He has a history of intellectual disability and self-mutilating behavior such as excessive nail biting. The image below shows the hand of a patient who suffers from the same condition. Which enzyme is most likely deficient in this patient?

Question 5 of 5


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