Reproductive Quiz #33, Breast Pathology  

1. A 50-year-old woman presents with a palpable mass in her right breast. Mammography reveals a 2 cm, well-defined, dense mass. Biopsy of the mass shows small, uniform cells forming glandular and tubular structures. Which of the following is the most likely diagnosis?

Question 1 of 5

2. A 65-year-old woman presents for her annual check-up. She has no complaints but her family history is significant for a sister with ovarian cancer. On examination, a lump is palpated in her left breast, and a biopsy reveals malignant cells that are positive for estrogen and progesterone receptors and negative for HER2/neu overexpression. Given her family history, which genetic mutation is most likely associated with her breast cancer?

Question 2 of 5

3. A 40-year-old woman presents with a hard, irregular mass in her left breast. Biopsy of the mass reveals malignant cells arranged in Indian file patterns and signet ring cells. Which of the following is the most likely diagnosis?

Question 3 of 5

4. A 55-year-old woman presents with nipple retraction and a palpable mass in her right breast. A biopsy is performed, and histological analysis reveals cancer cells surrounded by dense fibrous stroma. The cells stain positive for E-cadherin. Based on the histological findings, which of the following is the most likely diagnosis?

Question 4 of 5

5. A 47-year-old woman undergoes a biopsy for a suspicious breast lesion. Histology shows large cells with abundant cytoplasm and central nuclei, forming solid nests. The lesion is sharply demarcated from the surrounding tissue. Immunohistochemistry is positive for GCDFP-15. Which of the following is the most likely diagnosis?

Question 5 of 5


 

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