Respiratory Quiz #8, Hemoglobin and hemoglobinopathies 

1. A 6-month-old infant presents with severe anemia, failure to thrive, and recurrent bacterial infections. Laboratory tests reveal hemolytic anemia with target cells present on the peripheral smear. Genetic analysis indicates a mutation leading to the absence of beta-globin chains. This condition is best diagnosed as: 

Question 1 of 6

2. A 15-year-old African American boy is admitted to the hospital with severe pain in his legs and back, a condition he has experienced multiple times in the past. His peripheral blood smear shows sickled cells. Which of the following genetic mutations is most likely responsible for his condition?

Question 2 of 6

3. During a biochemistry lecture, a medical student learns that 2,3-bisphosphoglycerate (2,3-BPG) binds to hemoglobin and decreases its affinity for oxygen. This mechanism is important for facilitating oxygen unloading in tissues. In which condition would you expect the concentration of 2,3-BPG to be increased? 

Question 3 of 6

4. A newborn presents with cyanosis and a chocolate-brown colored blood that does not turn red upon exposure to room air. A diagnosis of methemoglobinemia is made. Which of the following agents is most effective in treating this condition?

Question 4 of 6

5. A 25-year-old Mediterranean man presents with splenomegaly, jaundice, and a history of gallstones. Laboratory tests reveal microcytic, hypochromic anemia, and target cells on the peripheral smear. A hemoglobin electrophoresis shows an increased level of hemoglobin A2. Which of the following is the most likely diagnosis? 

Question 5 of 6

6.

Question 6 of 6


 

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